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Thiamine Hydrochloride (VB1) in Water: A Privileged Synthetic Route to Benzimidazole Derivatives

Suchita S. Gadekar, Suryakant B. Sapkal, Balaji R. Madje

Abstract


Thiamine hydrochloride (VB1) is found to be an inexpensive, efficient, non-toxic and mild catalyst for the cyclocondensation of o-phenylinediamine and
aromatic/heteroaromatic/aliphatic aldehydes in water at moderate temperature. The present work contributes a greener approach for the synthesis of benzimidazole derivatives under gracious (water) reaction medium which resulted into facile, sustainable and high yielding methodology.

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