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Green synthesis of copper nanoparticles using methanol extract of Passiflora foetida and its drug delivery applications

Kirubandanan S, V. Subha, S. Renganathan

Abstract


The present study outlines a green synthetic approach on copper nanoparticles by mixing the copper salt solution with a methanol extract of leaves of Passiflora foetida. The plant extract play as a reducing agent for copper ions in copper solution into copper nanoparticles providing a safer process. The plant extract contains numerous secondary metabolites involving in the reduction of copper ions into forming nanoparticles. The spectroscopic analysis of green synthesized copper nanoparticles confirms the maximum absorbance at 407 nm demonstrating the copper nanoparticles in the reaction mixture. The FT-IR spectra of the CuNPs indicate the lowering of peak intensity for O-H stretch of a phenolic compound, confirming the reduced and stabilized copper nanoparticles. The size of the CuNPs ranges from 150 to 300 nm evaluated via SEM and the average particle diameter of CuNPs is 318nm and Polydispersity index is 0.200 measured via dynamic scattering method. EDAX analysis of CuNPs depicting 49.95 weight % of copper and 50.05 weight % of oxygen and confirming oxidation of CuNPs into copper oxide. The XRD spectra of CuNPs confirms that the peaks are observed at 2θ values of 42.47, 51.73 and 73.42 correspond to (111), (200) and (220) planes of zero-valent copper nanoparticles. The bio-synthesised CuNPs is a potent antimicrobial agent against both gram positive and negative microbes. These CuNPs are capable of conjugating with Atorvastatin, an anti-cholesteric compound for drug delivery studies and its interaction is complex formation. Therefore, Green synthesis of CuNPs is an inexpensive process, safer reaction environment with avoiding hazardous and toxic reagents and pollution free.

Keywords: Green synthesis, Passiflora foetida, Copper Nanoparticles and Atorvastatin

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