Open Access Open Access  Restricted Access Subscription or Fee Access

Green synthesis of copper nanoparticles using methanol extract of Passiflora foetida and its drug delivery applications

Kirubandanan S, V. Subha, S. Renganathan

Abstract


The present study outlines a green synthetic approach on copper nanoparticles by mixing the copper salt solution with a methanol extract of leaves of Passiflora foetida. The plant extract play as a reducing agent for copper ions in copper solution into copper nanoparticles providing a safer process. The plant extract contains numerous secondary metabolites involving in the reduction of copper ions into forming nanoparticles. The spectroscopic analysis of green synthesized copper nanoparticles confirms the maximum absorbance at 407 nm demonstrating the copper nanoparticles in the reaction mixture. The FT-IR spectra of the CuNPs indicate the lowering of peak intensity for O-H stretch of a phenolic compound, confirming the reduced and stabilized copper nanoparticles. The size of the CuNPs ranges from 150 to 300 nm evaluated via SEM and the average particle diameter of CuNPs is 318nm and Polydispersity index is 0.200 measured via dynamic scattering method. EDAX analysis of CuNPs depicting 49.95 weight % of copper and 50.05 weight % of oxygen and confirming oxidation of CuNPs into copper oxide. The XRD spectra of CuNPs confirms that the peaks are observed at 2θ values of 42.47, 51.73 and 73.42 correspond to (111), (200) and (220) planes of zero-valent copper nanoparticles. The bio-synthesised CuNPs is a potent antimicrobial agent against both gram positive and negative microbes. These CuNPs are capable of conjugating with Atorvastatin, an anti-cholesteric compound for drug delivery studies and its interaction is complex formation. Therefore, Green synthesis of CuNPs is an inexpensive process, safer reaction environment with avoiding hazardous and toxic reagents and pollution free. Keywords: Green synthesis, Passiflora foetida, Copper Nanoparticles and Atorvastatin

Full Text:

PDF

References


Angrasan JKVM and Subbaiya. Biosynthesis of copper nanoparticle by Vitis vinifera Leaf aqueous extract and its Antibacterial Activity. International Journal of Current Microbiology and Applied Sciences 2014; 3(9):768-774.

Ashajyothi C, Kudsi J and Kelmani CR. Biosynthesis and characterization of copper nanoparticles from Enterococcus faecalis. International Journal of Pharma and Bio Sciences2014; 5(4):204-211.

Athanassiou EK, Grass RN and Stark WJ. Large scale production of carbon coated copper nanoparticles for sensor applications. Nanotechnology 2006; 17:1668-1673.

Athawale AA, Kater PP, Kumar K, Majumdar MB, Copper nanoparticles, Materials Chemistry and Physics 2005; 91:507-512.

Barrabes N, Just J, Dafinov A, Medina F, Fierro JLG, Sueiras JE, Salagre P and Cesteros Y. Catalytic reduction of nitrate on Pt-Cu and Pd-Cu on active carbon using continuous reactor: The effect of copper nanoparticles. Applied Catalysis B:Environmental2006; 62:77.

Clavee GN, Jungbaur M and Jackelen AL. Langmuir 1999; 15:2322.

Dadgostar N. Investigations on colloidal synthesis of copper nanoparticles in a two-phase liquid-liquid system. M.Sc. Thesis, Waterloo, Ontario, Canada, (2008).

Dash PK and Balto Y. Generation of Nanocopper Particles through Wire Explosion Method and its Characterization. Journal of Nanoscience and Nanotechnology 2011; 1:25.

Elumalai EK, Prasad VK, Hemachandran J, Theresa SV, Thirumalai T and David E. Extracellular synthesis of nanoparticles using leaves of Euphorbia hirta. Journal of Pharmaceutical Science and Research 2010; 2(9):549-554.

Ghorba HR, Mehr FPand Poor AK. Extracellular synthesis of copper nanoparticles using culture supernatants of Salmonella typhimurium. Oriental Journal of Chemistry 2015;31(1).

Gopinath M, Subbaiya R, Selvam MM and Suresh D. Synthesis of Copper Nanoparticles from Nerium oleander Leaf aqueous extract and its Antibacterial Activity. International Journal of Current Microbiology and Applied Sciences2014; 3(9):814-818.

Jha AK, Prasad K, Prasad K and Kulkarni AR. Plant system: nature's nanofactory. Colloids and Surfaces B: Biointerfaces 2009; 73:219–223.

Kapoor S and Mukherjee T Photochemical formation of copper nanoparticles in poly(N-vinylpyrrolidone). Chemical physics letters 2003; 370(1-2):83-87.

Khalil H, Mahajan D, Rafailovich M, Gelfer M and Pandya K. Langmuir 2004;20: 6896.

Kildeby NL, Andersen OZ, Roge RE, Larsen T, Petersen R and Riis JF. Project on silver nanoparticles. Faculty of Physics and Nanotechnology; Aalborg University 2006; 3-10.

Kim BS, Lee H and Song JY, Biological synthesis of copper nanoparticles using Magnolia kobus leaf extract and their antibacterial activity. Journal of Chemical Technology & Biotechnology 2013; 88(11).

Kinemuchi Y, Murai K, Sangurai C, Cho CH, Suematsu H, Jiang W, Yatsui K. Nanosize powders of aluminum nitride synthesized by pulsed wire discharge. Journal of American Ceramic Society 2003; 86(3):420.

Kotov YA. Journal of NanoparicleResearch 2003; 5:539.

Lisiecki I and Pileni MP. Synthesis of copper metallic clusters using reverse micelles as microreactors. Journal of the American chemical society 1993; 115:3887-3896.

Lisiecki I, Billoudet F and Pileni MP. Control of the Shape and the Size of Copper Metallic Particles. The Journal of physical Chemistry 1996; 100:4160-4166.

Lisiecki I, Billoudet F and Pileni P. Control of the shape and the size of copper metallic particles. The Journal of Physical Chemistry 1996; 100:4160.

Lisiecki I, Filankembo A, Sack-Kongehl H, Weiss K, Pileni MP and Urban J. Structural investigations of copper nanorods by high-resolution TEM. Physical Review B Condensed Matter 2000; 61:4968.

Mallikarjuna K, Narasimha G, Dillip GR, Praveen B, Shreedhar B, Shreelakshmi C, Reddy VS and Devaprasad RB. Green synthesis of silver nanoparticles using Ocimum leaf extract and their characterization. Digest Journal of Nanomaterials and Biostructures 2011; 6(1):181-186.

Marine W, Patrone L, Luk'yanchuk B and Sentis M. Strategy of nanocluster and nanostructure synthesis by conventional pulsed laser ablation. Applied Surface Science 2000; 154:345-352.

Mott D, Galkowski J, Wang L, Luo J and Zhang CJ. Synthesis of size- controlled and shaped copper nanoparticles. Langmuir 2007; 23(10):5740-5745.

Murai K, Watanabe Y, Saito Y, Nakayama T, Suematsu H, Jiang W, Yatsui K, Shim KB and Niihara K. Preparation of copper nanoparticles with an organic coating by a pulsed wire discharge method. Journal of Ceramic processing Reasearch 2007; 8:114.

Namboodiri VV and Varma RS. Solvent-free preparation of ionic liquids using household microwave oven. Green Chemistry 2001; 3:146.

Nikhil J, Zhong, L. W, Tapan KS and Tarasankar P. Seed-mediated growth method to prepare cubic copper nanoparticles. Current Science 2000; 79(9):1367-1370.

Panigrah S, Kundu S, Ghosh SK, Nath S, Praharaj S, Soumen B and Pal T. Selective one-pot synthesis of copper nanorods under surfactant less condition. Polyhydron 2006; 25:1263-1269.

Park BK, Jeong S, Kim D, Moon J, Lim and Kim JS. (2007). Synthesis and size control of monodisperse copper nanoparticles by polyol method. Journal of Colloid and Interface Science 2007; 311(2):417-424.

Pavani KV, Srujana N, Preethi G and Swati T. Synthesis of copper nanoparticles by Aspergillus species. Letters in Applied NanoBioScience 2013; 2(2):110-113.

Pol VG, Motiei M, Gedanken A and Mastai Y. Sonochemical Deposition of Air-Stable Iron Nanoparticles on Monodispersed Carbon Spherules. Chemistry of Materials (2003); 15(6):1378-1384.

Sadowski Z. Biosynthesis and applications of silver and gold nanoparticles. Silver Nanoparticles, David Pozo Perez (Ed.) 2010; ISBN: 978-953-307-028-5, In Tech, 257-276.

Saito M and Yasukawa K. Copper nanoparticles fabricated by laser ablation in polysiloxane. Optical Materials 2008; 30:1201.

Salzemann C, Lisiecki I, Brioude A, Urban and Pileni MP. Collections of copper nanocrystals characterized by different sizes and shapes: Optical response of these nanoobjects. The Journal of Physical Chemistry B 2004; 108(35):13242–13248.

Sasikala V, Saravana S and Parimelazhagan T. Evaluation of antioxidant potential of different parts of wild edible plant Passiflora foetida L. Journal of Applied Pharmaceutical Science 2011; 1(04):89-96.

Shantkriti S and Rani P. Biosynthesis of copper nanoparticle by Pseudomonas fluorescens. International Journal of Current Microbiology and Applied Sciences2014; 3(9):374-383.

Shobha G, Vinutha M and Ananda S. Biological synthesis of copper nanoparticles and its impact. International Journal of Pharmaceutical Science Invention 2015.

Soomro R, Sherazi S, Sirajuddin MN, Shah M, Kalwar N, Hallam K and Shah AV.Synthesis of air stable copper nanoparticles and their use in catalysis. Advanced Materials Letters 2014;5:191-198.

Suslick K S, Choe SB, Cichowlas AA and Grinsta MW. Nature 1991.

Varshney R, Bhadauria S and Gaur MS. Biological Synthesis of Silver and Copper Nanoparticles. Nano Biomedicine and Engineering 2012; 4(2):99-106.

Vyas SP and Khar RK. Targeted and Controlled Drug Delivery- Novel Carrier Systems, New Delhi: CBS Publication 2004; First edition; 331.

Wang Y, Chen P and Liu M. Nanotechnology 2006; 17:6000.

Wardencki W, Curylo J and Namiesnik J. Green Chemistry-Current and future issues. Polish Journal of Environmental Studies 2005; 14(4):389-395.

Zain NM, Stapley AGF and Shama G. Green synthesis of silver and copper nanoparticles using ascorbic acid and chitosan for antimicrobial applications. Carbohydrate Polymers 2014; 112:195 - 202.

Zhu H, Zhang C and Yin Y. Nanotechnology 2005;16:3070.

Prabhu V, Uzzaman S, Grace VMB and Guruvayoorappan C. Nanoparticles in Drug Delivery and Cancer Therapy: The Giant Rats Tail. Journal of Cancer Therapy 2011; 2: 325-334.

Zhang R, Pan D, Cai X, Yang X, Senpan A, Allen JS, Lanza GM and Wang LV. ανβ3-targeted Copper Nanoparticles Incorporating an Sn 2 Lipase-Labile Fumagillin Prodrug for Photoacoustic Neovascular Imaging and Treatment.Theranostics 2015; 5(2): 124–133.

Chaudhary A, Dwivedi C, Gupta A and Nandi CK. One pot synthesis of doxorubicin loaded gold nanoparticles for sustained drug release. RSC Adv 2015; 5: 97330.

Ghosh S, More P , Nitnavare R , Jagtap S , Chippalkatti R , Derle A , Kitture R , Asok A , Kale S, Singh S , Shaikh ML , Ramanamurthy B , Bellare J and Chopade BA. Antidiabetic and Antioxidant Properties of Copper Nanoparticles Synthesized by Medicinal Plant Dioscorea bulbifera. J Nanomed Nanotechnol 2015; S6.

Zhang L, Li Y Jin Z, Yu JC and ChanKM. A NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates. Nanoscale 2015; 7:12614-12624.

Baur AW, Kirby WMM, Sherris JC, Turck M. Antibiotic Susceptibility testing by a standardized single disk method. Am J ClinPathol 1996; 45:493-496.

Braca A, Sortino C, Politi M . Antioxidant activity of flavonoidsfrom Licania licaniaeflora. J. Ethnopharmacol 2002; 79: 379-381.

Kadu PJ, Kushare SS, Thacker DD, Gattani SG. Enhancement of oral bioavailability of atorvastatin calcium by self-emulsifying drug delivery systems (SEDDS). Pharm Dev Technol. 2011; 16: 65–74.

Asir PJ, Priyanga S, Hemmalakshmi S and Devak K. In Vitro free radical scavenging activity and secondary metabolites in Passiflora foetida L. Asian J Pharmaceut Res Health Care 2011; 6(2):3-11.

Martis P, Fonseca A, Mekhalif Z and Delhalle J. Optimization of cuprous oxide nanocrystals deposition on multiwalled carbon nanotubes. J. Nanopart. Res.2010 ;12 : 439–448.

Waseda Y, Matsubara E, Shinoda K. X-ray diffraction crystallography: introduction, examples and solved problems.Springer (2011)

Kulkarni VD and Kulkarni PS. Green Synthesis of Copper Nanoparticles Using OcimumSanctum Leaf Extract International Journal of Chemical Studies; 1(3): 2321-4902.

Osawa T. Novel natural antioxidants for utilization in food and biological systems. In: Uritani I, Garcia VV,Mendoza EM (Eds) Post harvest biochemistry of plant food-materials in the tropics. Japan Scientific Societies Press 1994: 241-251.


Refbacks

  • There are currently no refbacks.