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MULBERRY, MORUS ALBA (L): THE GLOBAL MEDICINAL HERITAGE

Vitthalrao Bhimasha Khyade, Avram Hershko

Abstract


Mulberry, Morus alba (L) is a fast-growing, small to medium-sized mulberry tree which grows to 10–20 m tall. It is generally a short-lived tree with a lifespan comparable to that of humans, although there are some specimens known to be over 250 years old The species is native to northern China, and is widely cultivated and naturalized elsewhere (United States, Mexico, Australia, Kyrgyzstan, Argentina, Turkey, Iran, etc.). Hypolipidemic and antioxidant effects from freeze-dried powder of mulberry (Morus alba L.) fruit Neuroprotective effects in in vitro and in vivo (fruit) Albanol A, isolated from the root bark extract of M. alba, may be a promising lead compound for developing an effective drug for treatment of leukemia. Moracin M, steppogenin-4′-O-β-D-glucoside and mulberroside A were isolated from the root bark of Morus alba L. and all produced hypoglycemic effects. Mulberroside A, a glycosylated stilbenoid, can be useful in the treatment of hyperuricemia and gout. A methanol extract of Morus alba roots showed adaptogenic activity, indicating its possible clinical utility as an antistress agent. Morus alba leaf extract help restore the vascular reactivity of diabetic rats. Free radical-induced vascular dysfunction plays a key role in the pathogenesis of vascular disease found in chronic diabetic patients. An ethanolic extract of mulberry leaf had antihyperglycemic, antioxidant and antiglycation effects in chronic diabetic rats, which may suggest its use as food supplement for diabetics. KEY WORDS: Anthocyanin, Antioxidants, β-sitosterol, Flavonoids, Mulberry, Phytochemical.

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Srivastava R, Kapoor A, Thathola RP, Srivastava. Mulberry (Morus alba) leaves as human food: a new dimension of sericulture. Int J Food Sci Nutr, 2003; 54: 411-416.

Pan G, Lou CF. Isolation of a 1-aminocyclopropane-1-carboxylate oxidase gene from mulberry (Morus alba L.) and analysis of the function of this gene in plant development and stresses response. J Plant Physiology, 2008; 165: 1204-1213.

Perez-Gregorio RM, Regueiro J, Alonso-González EL, Pastrana-Castro M, Simal-Gándara J. Influence of alcoholic fermentation process on antioxidant activity and phenolic levels from mulberries (Morus nigra L.). LWT – Food Sci Tech, 2011; 44(8): 1793-1801.

Yang X, Yang L, Zheng H. Hypolipidemic and antioxidant effects of mulberry (Morus alba L.) fruit in hyperlipidemia rats. Food Chem Toxicol, 2010; 48(8-9): 2374-2379.

Gerasopoulos D, Stavroulakis G. Quality characteristics of four mulberry (Morus spp.) cultivars in the area of Chania Greece. J Sci. Food Agric, 1997; 73: 261-264.

Ercisli S, Orhan E. Chemical composition of white (Morus alba), red (Morus rubra) and black (Morus nigra) mulberry fruits. Food Chem, 2007; 103: 1380-1384.

Somasundaram A, Arumugam, Rajarajan T, Thandavarayan, Punniyakoti, Veeraveedu, Meilei Ma V, Vijayasree, Giridharan, Wawaimuli Arozal R, Flori, Sari, Vijayakumar Sukumaran, Arunprasath Lakshmanan, Vivian Soetikno, Kenji Suzuki, Makoto Kodama,

Kenichi Watanabe. Modulation of endoplasmic reticulum stress and cardiomyocyte apoptosis by mulberry leaf diet in experimental autoimmune myocarditis rats. J Clinical Biochem Nutri, 2012; 50(2): 139-144.

Shibata Y, Kume N, Arai H, Hayashida K, Inui-Hayashida A, Minami M, Mukai E, Toyohara M, Harauma A, Murayama T, Kita T, Hara S, Kamei K, Yokode M. Mulberry leaf aqueous fractions inhibit TNF-alpha-induced nuclear factor kappaB (NF-kappaB) activation and lectin-like oxidized LDL receptor-1 (LOX-1) expression in vascular endothelial cells. Atherosclerosis, 2007; 193(1): 20-27.

Chan KC, Ho HH, Huang CN, Lin MC, Chen HM, Wang CJ. Mulberry leaf extract inhibits vascular smooth muscle cell migration involving a block of small GTPase and Akt/NF-kappaB signals. J Agric Food Chem, 2009; 57: 9147-9153.

Elmaci Y, Altug T. Flavour evaluation of three black mulberry (Morus nigra) cultivars using GC/MS. Chemical and sensory data. J Sci Food Agric, 2002; 82(6): 632-635.

Darias-Martin J, Lobo-Rodrigo G, Hernandez-Cordero J, Diaz-Diaz E, Diaz-Romero C. Alcoholic beverages obtained from black mulberry. Food Technol Biotech, 2003; 41(2): 173-176.

Lin JY, Tang CY. Determination of total phenolic and flavonoid contents in selected fruits and vegetables as well as their stimulatory effects on mouse splenocyte proliferation. Food Chem, 2007; 101(1): 140-147.

Yogananda Murthy VN, Ramesh HL, Lokesh G, Munirajappa, Dayakar Yadav BR. Leaf quality evaluation of ten mulberry (Morus) germplasm varieties through phytochemical analysis. Int J Pharm Sci Rev Res, 2013; 21(1): 182-189.

Deshmukh SV, Pathak NV, Takalikar DA. Nutritional effect of mulberry (Morus alba) leaves as sole ration of adult rabbits. World Rabbit Sci J, 1993; 1: 67-69.

Kang TH, Hur JY, Kim HB, Ryu JH, Kim SY. Neuroprotective effects of the cyaniding-3-O--glucopyranoside isolated from mulberry fruit against cerebral ischemia. Neurosci Lett, 2006; 391: 168-172.

Li LN. Biologically active components from traditional Chinese medicines. Pure Appl Chem, 1998; 70: 547-554.

Nomura T, Fukai T, Kuwanon G. A new flavone derivative from the root barks of the cultivated mulberry tree (Morus alba L.). Chem Pharm Bull, 1980; 28: 2548-2552.

Butt MS, Nazir A, Sultan MT, Schroen K. Morus alba L. nature‟s functional tonic. Trends Food Sci Technol, 2008; 19: 505-512.

Das BC, Krishnaswami S. Some observations on interspecific hybridization in mulberry. Indian J Seric, 1965; 4: 1-8.

Mehla RK, Patel RK, Tripathi VN. A model for sericulture and milk production. Agricultural systems, 1987; 25: 125-133.

Datta RK. Mulberry Cultivation and Utilization in India. FAO. Electronic conference on mulberry for animal production, Mulberry cultivation and utilization in India. Rome, Italy, 2000; 45-62.

Vijayan K, Srivastava PP, Awasthi AK. Analysis of phylogenetic relationship among five mulberry (Morus) species using molecular markers. Genome, 2004; 47: 439-448.

Hasimoto NM, Genovese MI, Lajola FM. Absorption and metabolism of cyaniding-3-glucoside and cyaniding-3-rutinoside extracted from wild mulberry (Morus nigra L.) in rats. Natr Res, 2008; 28(3): 198-207.

Kimura T, Nakagawa K, Kubota H. Food-grade mulberry powder enriched with1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agri Food Chem, 2007; 55: 5869-5874.

Nakagawa K, Ogawa K, Higuchi O, Kimura T, Miyazawa T, Hori M. Determination of iminosugars in mulberry leaves and silkworms using hydrophilic interaction chromatography –tandem mass spectrometry. Analytical Biochem, 2010; 404: 217-222.

Bae SH, Suh HJ. Antioxidant activities of five different mulberry cultivars in Korea. LWT-Food Sci Technol, 2007; 40: 955-962.

Chao WW, Kuo YH, Li WC, Lin BF. The production of nitric oxide and prostaglandin E2 in peritoneal macrophages is inhibited by Andrographis paniculata, Angelica sinensis and Morus alba ethyl acetate fractions. J Ethnopharmacol, 2009; 122(1): 68-75.

Choi EM, Hwang JK. Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines in RAW2647 macrophages. Fitoterapia, 2005; 76: 608-613.

Zheng ZP, Tan HY, Wang M. Tyrosinase inhibition constituents from the root of Morus australis. Fitoterapia, 2012; 83(6): 1008-1013.

Nitra N, Kornkanok I, Wiroje K, Sathaporn W, Bhinai H. Quantitative determination of 1-deoxynojirimycin in mulberry leaves using liquid chromatography-tandem mass spectrometry. J Pharmaceut Biomed Analysis, 2007; 44(4): 853-858.

Cui XQ, Wang L, Yan RY, Tan YX, Chen RY, Yu DQ. A new Diels-Alder type adducts and two new flavones from the stem bark of Morus yunanensis Koidz. J Asian Nat Prod Res, 2008a; 10(3-4): 361-366.

Ozgen M, Serce S, Kaya C. Phytochemical and antioxidant properties of anthocyanin rich Morus nigra and Morus rubra fruits. Sci Hortic, 2009; 119: 275-279.

Daimon T, Hirayama C, Kanai M, Ruike Y, Meng Y, Kosegawa E, Nakamura M, Tsujimoto G, Katsuma S, Shimada T. The silkworm Green b locus encodes a quercetin f-O-glucosyltransferase that produces green cocoons with UV-shielding properties. Proc Natl Acad Sci USA, 2010; 107(25): 11471-11476.

Ajitha M, Rajnarayana K. Indian Drugs. 2001; 38(11): 545-553.

Mehdy MC. Active oxygen species in plant defense against pathogens. Plant Physiol, 1994; 105: 467-472.

Elfalleh W, Tlili N, Nasri N, Yahia Y, Hannachi H, Chaira N. Antioxidant capacities of phenolic compounds and tocopherols from tunisian pomegranate (Punica granatum) fruits. J Food Sci, 2011; 76: 707-713.

Goud PB, Kachole MS. Antioxidant enzyme changes in neem, pigeonpea and mulberry leaves in two stages of maturity. Plant Signal Behav, 2012; 7(10): 1258-1262.

Sreelatha S, Padma PR. Antioxidant activity and total phenolic content of Moringa oleifera leaves in two stages of maturity. Plant Foods Hum Nutr, 2009; 64: 303-311.

Singhania N, Puri D, Madhu SV, Sharma SB. Assessment of oxidative stress and endothelial dysfunction in Asian Indians with type 2 diabetes mellitus with and without macroangiopathy, QJM, 2008; 101(6): 449-455.

Pihlanto A, Akkanen S, Korhonen HJ. ACE-inhibitory and antioxidant properties of potato (Solanum tuberosum). Food Chem, 2008; 109: 104-112.

Jiang YL, Piao HS, Li G. Study on antioxidant activity of constituents from mulberry leaf. Zhong Yao Cai, 2008; 31(4): 519-522.

Wang W, Zu Y, Fu Y, Efferth T. In vitro antioxidant and antimicrobial activity of extracts from Morus alba L. leaves, stems and fruits. J Food Sci, 2011; 76(6): 869-873.

Zhang M, Chen M, Zhang HQ, Sun S, Xia B, Wu FH. In vivo hypoglycemic effects of phenolics from the root bark of Morus alba. Fitoterapia, 2009; 80(8): 475-477.

Imran M, Khan H, Shah M, Khan R, Khan F. Chemical composition and antioxidant activity of certain Morus species. J Zhejiang Univ Sci, 2011; 11: 973-980.

Awad NE, Seida AA, Hamed MA, Hosny AM, Elbatanony MM. Phytochemical and in vitro screening of some Ficus and Morus spp. For hypolipidaemic and antioxidant activities and in vivo assessment of Ficus mysorensis (Roth.). Nat Prod Res, 2012; 26: 1101-1111.

Ahmad A, Gupta G, Afzal M, Kazmi I, Anwar F. Antiulcer and antioxidant activities of a new steroid from Morus alba. Life Sci, 2013; 92(3): 202-210.

Tewari RK, Kumar P, Sharma PN. Antioxidant responses to enhanced generation of superoxide anion radical and hydrogen peroxide in the copper-stressed mulberry plants. Fitoterapia, 2005; 76(7-8): 608-613.

Khan MA, Rahman AA, Islam S, Khandokhar P, Parvin S, Islam MB, Hossain M, Rashid M, Sadik G, Nasrin S, Mollah MN, Alam AH. A comparative study on the antioxidant activity of methanolic extracts from different parts of Morus alba L. (Moraceae). BMC Res Notes, 2013; 6: 24.

Jin YS, Lee MJ, Han W, Heo SL, Sohn SL, Wang MH. Antioxidant effects and hepatoprotective activity of 2,5-dihydroxy-4,3-di(beta-d-glucopyranosyloxy)-trans-stilbene from Morus bombycis Koidzumi roots on CCI4-induced liver damage in vivo. Free Rad Res, 2006; 40(9): 986-992.

Cui X, Wang H, Liu C, Chen RY. Study of antioxidant phenolic compounds from stem barks of Morus yunanensis. Zhonggno Zhong Yao Za Zhi, 2008b; 33(13): 1569-1572.

Sharma R, Sharma A, ShonoT, Takasugi M, Shirata A, Fujimora T, Machii H. Mulberry moracins: Scavangers of UV-stress generated free radicals. Biosci Biotechnol Biochem, 2001; 65(6): 1402-1405.

Lee CY, Cheng HM, Sim SM. Mulberry leaves protect rat tissues from immobilization stress-induced inflammation. Biofactors, 2007a; 31(1): 25-33.

Kalkan YH. Evaluation of colour parameters and antioxidant activities of fruit wines. Int J Food Sci Natr, 2006; 57(1-2): 47-63.

Isabelle M, Lee BL, Ong CN, Liu X, Huang D. Peroxyl radical scavenging capacity, polyphenolics and lipophilic antioxidant profiles of mulberry fruit cultivated in southern China. J Agric Food Chem, 2008; 56(20): 9410-9416.

Chen Z, Zhu C, Han Z. Effects of aqueous chlorine dioxide treatment on nutritional components and shelf-life of mulberry fruit (Morus alba L.). J Biosci Bioeng, 2011; 111(6): 675-681.

Rossetto M, Vanzani P, Lunelli M, Scarpa M, Mattivi F, Rigo A. Peroxyl radical trapping activity of anthocyanins and generation of free radical intermediates. Free Radic Res, 2007; 41: 854-859.

Kapche GD, Fozing CD, Donfck JH, Fotso GW, Amadou D, Tchana AN, Bezabih M, Moundipa PF, Ngadjui BT, Abegaz BM. Prenylated arylbenzofuran derivatives from Morus mesozygia with antioxidant activity. Biol Phram Bull, 2009; 32(1): 86-90.

Zafar MS, Muhammad F, Javed I, Akhtar M, Khaliq T, Aslam B, Waheed A, Yasmin R, Zafar H. White mulberry (Morus alba): A brief phytochemical and pharmacological evaluations account. Int J Agric Biol, 2013; 15: 612-620.

Zou Shengqin, Chen Wu. A review on chemical constituents, pharmacological activity and application of mulberry leaves. J Chem Indus Forest Products, 2003; 1: 22-25.

Venkatesh Kumar R, Seema Chauhan. Mulberry: Life enhancer. J Medicinal Plants Research, 2008; 2(10): 271-278.

Andallu B, Suryakantham V, Srikanthi BL, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta, 2001; 314: 47-53.

Andallu B, Varadacharyulu Nch. Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats. Clin Chim Acta, 2003; 338(1-2): 3-10.

Singhal BK, Khan MA, Dhar A, Baqual FM, Bindroo BB. Approaches to industrial exploitation of mulberry (Morus sp.) fruits. J Fruit Ornam Plant Res, 2010; 18(1): 83-99.

Doi K, Kojima T, Makino M, Kimura Y, Fujimoto Y. Studies on the constituents of the leaves of Morus alba L. Chem Pharm Bull, 2001; 49(2): 151-153.

Song W, Wang HJ, Bucheli P, Zhang PF, Wei DZ, Lu YH. Phytochemical profiles of different mulberry (Morus) species from China. J Nutr Biochem, 2010; 21(7): 598-605.

Naowaboot J, Pannangpetch P, Kukongviriyapan V, Kongyingyoes B, Kukongviriyapan U. Antihyperglycemic, antioxidant and antiglycation activities of mulberry leaf extract in streptozotocin-induced chronic diabetic rats. Plant Foods Hum Nutr, 2009; 64: 116-121.

Shih PH, Chan YC, Liao JW, Wang MF, Yen GC. Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea) on senescence accelerated mice and prevention of Alzheimer‟s disease. Plant Foods Hum Nutr, 2009; 64(2): 116-121.

Ha US, Koh JS, Kim HS, Woo JC, Kim SJ, Jang H, Yoon BI, Hwang SY, Kim SW. Cyanidin-3-O--D-glucopyranoside concentrated materials from mulberry fruit have a potency to protect erectile function by minimizing oxidative stress in a rat model of diabetic erectile dysfunction. Am J Chin Med, 2012; 40(2): 349-356.

Amalesh S, Gouranga D, Sanjoy KD. Roles of flavonoids in plants. Int J Pharm Sci Tech, 2011; 6(1): 12-35.

Kurian JC. Plants That Heal. Vol. 2. Oriental Longman Publishing House. 2007; 92-93.

Kim SY, Gao JJ, Lee WC, Ryu KS, Lee KR, Kim YC. Antioxidative flavonoids from the leaves of Morus alba. Arch Pharm Res, 1999; 22(1): 81-85.

Lee CY, Sim SM, Cheng HM. Phenylacetic acids were detected in the plasma and urine of rats administered with low-dose mulberry leaf extract. Nutr Res, 2008; 28: 555-563.

Enkhmaa B, Shiwaku K, Katsube T, Kitajima K, Anuurad E, Yamasaki M, Yamane Y. Mulberry (Morus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice. J Nutr, 2005; 135: 729-734.

Chen J, Li X. Hypolipidemic effect of flavonoids from mulberry leaves in triton WR-1339 induced hyperlipidemic mice. Asia Pac J Clin Nutr, 2007; 16: 290-294.

Katsube T, Yamasaki M, Shiwaku K, Ishijima T, Matsumoto I, Abe K, Yamasaki Y. Effect of flavonol glycoside in mulberry (Morus alba) leaf on glucose metabolism and oxidative stress in liver in diet-induced obese mice. J Sci Food Agri, 2010; 90: 2386-2392.

Iqbal S, Younas U, Sirajuddin KW, Chan RA, Sarfraz, Uddin MK. Proximate composition and antioxidant potential of leaves from three varieties of mulberry (Morus sp.): A comparative study. Int J Mol Sci, 2012; 13: 6651-6664.

Kim GN, Jang HD. Flavonol content in the water extracts of the mulberry (Morus alba L.) leaf and their antioxidant capacities. J Food Sci, 2011; 76(6): C869-C873.

Kwak EJ, Lee JY, Choi IS. Physicochemical properties and antioxidant activities of Korean traditional alcoholic beverage, Yakju, enriched with mulberry. Semin Cutan Med Surg, 2012; 31(2): 133-139.

Ahmed S, Shakeel F. Voltammetric determination of antioxidant character in Berberis lycium Royel. Zanthoxylum armatum and Morus nigra Linn. plants. Pak J Pharm Sci, 2012; 25(3): 501-507.

Nam S, Jang HW, Shibamoto T. Antioxidant activities of extracts from teas prepared from medicinal plants Morus alba L., Camellia sinensis L. and Cudrania tricuspidata and their volatile components. J Agric Food Chem, 2012; 60(36): 9097-9105.

Jaruchotikamol A, Pannangpetch P. Cytoprotective activity of mulberry leaf extract against oxidative stress-induced cellular injury in rats. Pak J Pharm Sci, 2013; 26(1): 163-168.

Volpato GT, Calderon IM, Sinzato S, Campos KE, Rudge MV, Damasceno DC. Effect of Morus nigra aqueous extract treatment on the maternal-fetal outcome, oxidative stress status and lipid profile of streptozotocin-induced diabetic rats. J Ethno pharmacol, 2011; 138: 691-696.

Sakagami H, Asano K, Satoh K, Takahashi K, Terakubo S, Shoji Y, Nakashima H, Nakamura W. Antistress activity of mulberry juice in mice. In Vivo, 2006; 20(4): 499-504.

El-Beshbishy HA, Singab ANB, Sinkkonen J, Pihlaja K. Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats. Life Sci, 2006; 78: 2724-2733.

Oh H, Ko EK, Jun JY, Oh MH, Park SU, Kang KH. Hepatoprotective and free radical scavenging activities of prenylflavonoids, coumarin and stilbene from Morus alba. Planta Med, 2002; 68(10): 932-934.

Naderi GA, Asgary S, Sarraf-Zadegan N, Oroojy H, Afshin-Nia F. Antioxidant activity of three extracts of Morus nigra. Phytother Res, 2004; 18(5): 365-369.

Jin YS, Sa JH, Shim TH, Rhee HI, Wang MH. Hepatoprotective and antioxidant effects of Morus bombycis Koidzumi on CCI4-induced liver damage. Biochem Biophys Res Commun, 2005; 329(3): 991-995.

Hogade MG, Patil KS, Wadkar GH, Mathapati SS, Dhumal PB. Hepatoprotective activity of Morus alba (Linn.) leaves extract against carbon tetrachloride induced hepatotoxicity in rats. Afr J Pharm Pharmacol, 2010; 4: 731-734.

Hussein MS, El-Tawil OS, Yassin NEH, Abdou KA. The protective effect of Morus alba and Calendula officinalis plant extracts on carbon tetrachloride-induced hepatotoxicity in isolated rat hepatocytes. J Amer Sci, 2010; 6: 762-773.

Kapche GD, Amadou D, Waffo-Teguo P, Donfack JH, Fozing CD, Harakat D, Tchana AN, Merillon JM, Moundipa PF, Ngadjui BT, Abegaaz BM. Hepatoprotective and antioxidant arylbenzofurans and flavonoids from the twigs of Morus mesozygia. J Biosci Bioeng, 2011; 111(6): 675-681.

Yu Z, Fong WP, Cheng CH. Morin (3,5,7,2‟,4‟-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells. Drug Metab Dispos, 2007; 35: 981-986.

Wang L, Yang Y, Liu C, Chen RY. Three new compounds from Morus nigra L. J Asian Nat Prod Res, 2010; 12: 431-437.

Pirvulesen MM, Gan AM, Stan D, Simion V, Calin M, Butoi E, Tirgoviste CI, Manduteanu I. Curcumin and a Morus alba extract reduce pro-inflammatory effects of resistin in human endothelial cells. Phytother Res, 2011; 25(12): 1737-1742.

Tan YX, Liu C, Chen R. Phenolic constituents from stem bark of Morus wittiorum and their anti-inflammation and cytotoxicity. Zhongguo Zhong Yao Za Zhi, 2010; 35(20): 2700-2703.

Yang MY, Huang CN, Chan KC, Yang YS, Peng CH, Wang CJ. Mulberry leaf polyphenols possess anti-atherogenesis effect via inhibiting LDL oxidation and foam cell formation. J Agric Food Chem, 2011; 59(5): 1985-1995.

Liu LK, Lee HJ, Shih YW, Chyau CC, Wang CJ. Mulberry anthocyanin extracts inhibit LDL oxidation and macrophage-derived foam cell formation induced by oxidative LDL. J Food Sci, 2008; 73(6): H113-H121.

Harauma A, Murayama T, Ikeyama K, Sano H, Arai H, Takano R, Kita T, Hara S, Kamei K, Yokode M. Mulberry leaf powder prevents atherosclerosis in apolipoprotein E-deficient mice. Biochem Biophys Res Commun, 2007; 358(3): 751-756.

Kim HG, Ju MS, Shim JS, Kim MC, Lee SH, Huh Y, Kim SY, Oh MS. Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson‟s disease models. Brit J Nutr, 2010; 104: 8-16.

Zhang W, Han F, Duan C. HPLC-DAD-ESI-MS/MS analysis and antioxidant activities of non-anthocyanin phenolics in mulberry (Morus alba L.). J Food Sci, 2008; 73(51): 512-518.

Niidome T, Takahashi K, Goto Y, Goh SM, Tanaka N, Kamei K. Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity. Neuroreport, 2007; 18: 813-816.

Tian J, Fu F, Geng M, Jiang Y, Yang J, Jiang W, Wang C, Liu K. Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats. Neurosci Lett, 2005; 374: 92-97.

Kofujita H, Yaguchi M, Doi N, Suzuki K. A novel cytotoxic prenylated flavonoid from the root of Morus alba. J Insect Biotechnol Sericol, 2004; 73: 113-116.

Colonna M, Danzon A, Delafosse P, Mitton N, Bara S, Bouvier AM. Cancer prevalence in France: time trend situation in 2002 and extrapolation to 2012. Eur J Cancer, 2008; 44: 115-122.

Jeong JC, Jang SW, Kim TH, Kwon CH, Kim YK. Mulberry fruit (Morus fructus) extracts induce human glioma cell death in vitro through ROS-dependent mitochondrial pathway and inhibits glioma tumor growth in vivo. Nutr Cancer, 2010; 62(3): 402-412.

Prasad L, Khan TH, Sehrawat A, Sultana S. Modulatory effect of Morus indica against two-stage skin carcinogenesis in Swiss albino mice: possible mechanism by inhibiting aryl hydrocarbon hydroxylase. J Pharm Pharmacol, 2004; 56(10): 1291-1298.

Miyahara C, Miyazawa M, Satoh S, Sakai A, Mizusaki S. Inhibitory effects of mulberry leaf extract on postprandial hyperglycemia in normal rats. J Nutr Sci Vitaminol, 2004; 50: 161-164.

Mudra M, Ercan-Fang N, Zhong L. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75g sucrose by type-2 diabetic and control subjects. Diabetes Care, 2007; 30: 1272-1274.

Asai A, Nakagawa K, Higuchi O, Kimura T, Kojima Y, Kariya J, Miyazawa T, Oikawa S. Effect of mulberry leaf extract with enriched 1-deoxynojirimycin content on postprandial glycemic control in subjects with impaired glucose metabolism. J Diabetes Investigation, 2011; 2(4): 318-323.

Zhong L, Furne JK, Levitt MD. An extract of black, green and mulberry teas causes malabsorption of carbohydrate but not of triacylglycerol in healthy volunteers. Am J Clin Nutr, 2006; 84: 551-555.

Bonora E, Muggeo M. Postprandial blood glucose as a risk factor for cardiovascular disease in Type II diabetes: the epidemiological evidence. Diabetologia, 2001; 44: 2107-2114.

Van Der Laar FA, Lucassen PL, Akkermans RP. a-Glucosidase inhibitors for patients with type 2 diabetes: results from a Cochrane systematic review and meta-analysis. Diabetes Care, 2005; 28: 154-163.

Dungan KM, Buse JB, Largay J. 1,5-Anhydroglucitol and postprandial hyperglycemia as measured by continuous glucose monitoring system in moderately controlled patients with diabetes. Diabetes Care, 2006; 29: 1214-1219.

Nakamura M, Nakamura S, Oku T. Suppressive response of confections containing the extractive from leaves of Morus alba on postprandial blood glucose and insulin in healthy human subjects. Nutr Metab, (Lond). 2009; 6: 29.

Asano N, Yamashita T, Yasuda K, Ikeda K, Kizu H, Kameda Y, Kato A, Nash RJ, Lee HS, Ryu KS. Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). J Agric Food Chem, 2001; 49: 4208-4213.

Lee CY, Sim SM, Cheng HM. Systemic absorption of antioxidants from mulberry (Morus alba L) leaf extracts using an in situ rat intestinal preparation. Nutr Res, 2007b; 27: 492-497.

Kim GN, Kwon YI, Jang HD. Mulberry leaf extract reduces postprandial hyperglycemia with few side effects by inhibiting α-glucosidase in normal rats. J Med Food, 2011; 14: 712-717.

Sun F, Shen LM, Ma ZJ. Screening for ligands of human aromatase from mulberry (Morus alba L.) leaf by using high-performance liquid chromatography/ tandem mass spectrometry. Food Chem, 2011; 126: 1337-1343.

Ahmed H. Al-Mustafa, Osama Y. Al-Thunibat. Antioxidant activity of some Jordanian Medicinal plants used traditionally for treatment of Diabetes. Pak J Biol Sci, 2008; 11(3): 351-358.

Fang SH, Hou YC, Chao PD. Pharmacokinetic and pharmacodynamic interactions of morin and. J Nutr, 2005; 135(4): 729-734.

Vitthalrao B. Khyade, James P. Allison (2018). Utilization of the Aqueous Mulberry (Morus alba. L.) Leaf Decoction (AMLD) For Treating the DMBA Induced Hepatotoxicity and Free-Radical Damage in Norwegian Rat, Rattus norvegicus (L). International Journal of Scientific Research in Chemistry (IJSRCH) | IJSRCH | Volume 3 | Issue 5 ISSN: Page 106 – 123. 2456-8457 © 2018 IJSRCH |

Vitthalrao Bhimasha Khyade and Avram Hershko (2018). Use of Aqueous Decoction of Leaves of Mulberry, Morus alba (L) in Hyperglycemia-Induced Oxidative Stress in Brown Rat, Rattus norvegicus (L.). International Journal of Agro-Chemistry Vol 4, No 2 (2018): 01 – 23. eISSN: 2456-7000.www.journalspub.com

Vitthalrao Bhimasha Khyade and Avram Hershko (2018). Use of Aqueous Decoction of Leaves of Mulberry, Morus alba (L) in Hyperglycemia-Induced Oxidative Stress in Brown Rat, Rattus norvegicus (L.). International Journal of Agro-Chemistry Vol 4, No 2 (2018): 01 – 23. eISSN: 2456-7000.www.journalspub.com


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