Influence of Methanolic Extractives of Leaves of Mulberry, Morus alba (L) on the Hypercholesterolemia in Rat, Rattus norvegicus (L).

Vitthalrao Bhimasha Khyade; Michael Stuart Brown; Joseph Leonard Goldstein

Influence of Methanolic Extractives of Leaves of Mulberry, Morus alba (L) on the Hypercholesterolemia in Rat, Rattus norvegicus (L).

Vitthalrao Bhimasha Khyade, Michael Stuart Brown, Joseph Leonard Goldstein

Abstract

The methanolic mulberry leaf extractives (MMLE) (at the rate of 100 and 200 mg/kg body weight ) and the standard hypolipidemic medicine Questran were administered through the diet to the rats of hypercholesterolemia (maintained on high cholesterol diet). Treatment was five times per week for the period of nine weeks. Analysis of blood plasma and it’s postmitochondrial fraction (PMF) was carried out through the bioassay of total cholesterol; triglyceride; lipid peroxidation (LPO) and reduced glutathione. Treating the rats of hypercholesterolemia with MMLE caused the dose dependent reduction in cholesterol level in plasma and it’s PMF. The second dosage of Methanolic Mulberry Leaf Extractives (MMLE) (200 mg/kg) was significantly attenuated the cholesterol-induced increase in cholesterol plasma. Similarly, the cholesterol-induced decrease in PMF reduced glutathione levels of hypercholesterolemic rats were significantly ameliorated in experimental animals treated with Methanolic Mulberry Leaf Extractives (MMLE). The consumption of leaves of mulberry, Morus alba (L) may act as a potent hypocholesterolemic nutrient. Keywords: hypercholesterolemia, lipid-lowering effect, Morus alba, cholesterol

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