Review on Photochemical Process of DNA as a Biomolecule

Abstract

The UV-light induced isomerization mechanism between two photoproducts of DNA photo damage has been revealed in different biological environments. In association with DNA photo damage, the related photo repair processes have been proposed for different lesions in photo lyase which is a catalytic enzyme for DNA and the calculated results well explained the experimental observations. In particular, the internal and external properties of flavin cofactors have been extensively studied by combining the electronic structure and spectroscopic calculations. We have examined the effects of the intra molecular hydrogen bond on spectroscopic properties of flavins. The good quality agreements with the experimental spectra suggested that the biological self-regulation acted crucial role in these biological systems.
Keywords: photochemical, calculations, hydrogen, DNA, biomolecule, UV-light.