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Chitosan: Chemistry, Applications & Economics of Production - A Review

Sandeep Rai, K. Satish Kumar, Jinkal Mistry, Nilesh Singh, Akshita Rai


Chitosan is a natural poly-cationic linear polysaccharide derived from chitin and also known as de-acetylated chitin. It is derived from partial de-acetylation of chitin. Its low solubility in neutral and alkaline solution limits its application. Chitosan’s chemical modification brings to it new reactive functional properties for different applications. Because of biocompatibility, non-toxicity, low allergenicity and biodegradability, it is used in various applications .This review paper presents the chemistry, literature review of properties, applications and economics of production of chitosan.

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Venkatesan, J.; Kim, S.K. Chitosan composites for bone tissue engineering—An overview. Mar. Drugs 2010, 8, 2252–2266.

Karagozlu, M.Z.; Kim, S.-K. Chapter Twelve—Anticancer effects of chitin and chitosan derivatives. In Advances in Food and Nutrition Research; Kim, S.K., Ed.; Academic Press: Waltham, MA, USA, 2014; Volume 72, pp. 215–225.

Martins, A.F.; Facchi, S.P.; Follmann, H.D.; Pereira, A.G.; Rubira, A.F.; Muniz, E.C.Antimicrobial activity of chitosan derivatives containing N-quaternized moieties in its backbone:a review. Int. J. Mol. Sci. 2014, 15, 20800–20832.

Ngo, D.H.; Kim, S.K. Chapter Two—Antioxidant effects of chitin, chitosan, and their derivatives.In Advances in Food and Nutrition Research; Kim, S.K., Ed.; Academic Press: Waltham, MA, USA, 2014; Volume 73, pp. 15–31.

Aranaz, I.; Mengíbar, M.; Harris, R.; Paños, I.; Miralles, B.; Acosta, N.; Galed, G.; Heras, Á. Functional characterization of chitin and chitosan. Curr. Chem. Biol. 2009, 3, 203–230.

Onsosyen, E.; Skaugrud, O. Metal recovery using chitosan. J. Chem. Technol. Biotechnol. 1990,1. 49, 395-404.

Chandy, T.; Sharma, C.P. Chitosan-as a biomaterial. Biomater. Artif. Cells Artif. Organs 1990, 18, 1–24.

Felt, O.; Buri, P.; Gurny, R. Chitosan: A unique polysaccharide for drug delivery. Drug Dev. Ind.Pharm. 1998, 24, 979–993.

Han, L.K.; Kimura, Y.; Okuda, H. Reduction in fat storage during chitin-chitosan treatment in mice fed a high-fat diet. Int. J. Obes. Relat. Metab. Disord. 1999, 23, 174–179.

Zhang, Y.; Zhang, M. Three-dimensional macroporous calcium phosphate bioceramics with nested chitosan sponges for load-bearing bone implants. J. Biomed. Mater. Res. 2002, 61, 1–8.

Majeti N.V. Ravi Kumar, Reactive & Functional Polymers, 46(2000), 1-27.

Adarsh K.J and G.Madhu, International Journal of Innovative Research in Science, Engineering and Technology, Vol.3, Issue 2, February 2014, 9609-9617.

Varsha Panchal et al. , Journal of Pharmaceutical Erudition, Aug 2015, 5(2), 1-8.

14.Daniel Elieh-Ali-Komi and Michael R.Hamblin, International Journal of Advanced Research, Vol.4, Issue 3, 2016, 411-27.

Zyezdoya, D., Scientific Works of the Rousse University by Bulgaria,2010,49, pp 65-69.

A. Baxter, M. Dillon, K.D.A. Taylor, G.A.F. Roberts, Improved method for IR determination of the degree of N-acetylation of chitosan, Int. J. Biol. Macromol. 14 (1992) 166.

Qu x, Wiroen A & Albertsson AC, Polymer,2011,41,4841.

G.A. Maghami, G.A.F. Roberts, Studies on the adsorption of anionic dyes on chitosan, Makromol. Chem. 189 (1988) 2239.

A. Domard, Circular dichroism study on Nacetylglucosamine oligomers, Int. J. Biol. Macromol. 8 (1986) 243.

A. Domard, pH and c.d. measurements on a fully deacetylated chitosan: application to Cu II – polymer interactions, Int. J. Biol. Macromol. 9 (1987) 98.

Y.C. Wei, S.M. Hudson, Binding of sodium dodecyl sulfate to a polyelectrolyte based chitosan, Macromolecules 26 (1993) 4151.

H. Sashiwa, H. Saimoto, Y. Shigemasa, R. Ogawa, S. Tokura, Distribution of the acetamido group in partially deacetylated chitins, Carbohydr. Polym. 16 (1991) 291.

H. Sashiwa, H. Saimoto, Y. Shigemasa, S. Tokura, N-Acetyl group distribution in partially deacetylated chitins prepared under homogeneous conditions, Carbohydr. Res. 242 (1993) 167.

L. Raymond, F.G. Morin, R.H. Marchessault, Degree of deacetylation of chitosan using conductometric

titration and solid-state NMR, Carbohydr. Res. 243 (1993) 331.

F. Niola, N. Basora, E. Chornet, P.F. Vidal, A rapid method for the determination of the degree of N-acetylation of chitin – chitosan sample by acid hydrolysis and HPLC, J. Therm. Anal. 28 (1983) 189.

S.H. Pangburn, P.V. Trescony, J. Heller, in: J.P. Zikakis (Ed.), Chitin, Chitosan and Related Enzymes, Harcourt Brace Janovich, New York, 1984, p. 3.

T.D. Rathke, S.M. Hudson, Determination of the degree of N-deacetylation in chitin and chitosan as well as their monomer sugar ratios by near infrared spectroscopy, J. Polym. Sci., Polym. Chem. Ed. 31 (1993) 749.

Ioelovieh, M. , Research and Reviews; Journal of Chemical,2014,3(3),pp.7-14.

A.C.M. Wu, Determination of molecular weight distribution of chitosan by high-performance liquid chromatography, Methods Enzymol. 161 (1988) 447.

R.A.A. Muzzarelli, C. Lough, M. Emanuelli, The molecular weight of chitosan studied by laser light scattering, Carbohydr. Res. 164 (1987) 433.

P.K.Dutta et. Al, Journal of Scientific and Industrial Research, Vol. 63, Jan.2004, 20-31.

P. Madhavan (Ed.), Chitin, Chitosan and their Novel Applications, Science Lecture Series, CIFT, Kochi, 1992, p. 1.

P.K. Dutta, P. Viswanathan, L. Mimrot, M.N.V. Ravi Kumar, Use of chitosan amine oxide gel as drug carrier, J. Polym. Mater. 14 (1997) 351.

P.K. Dutta, M.N.V. Ravi Kumar, Chitosan – amine oxide: thermal behavior of new gelling system, Indian J. Chem. Technol. 6 (1999) 55.

M.N.V. Ravi Kumar, P. Singh, P.K. Dutta, Effect of swelling on chitosan– amine oxide gel in extended drug delivery, Indian Drugs 36 (1999) 393.

N. Nishi, J. Noguchi, S. Tokura, H. Shiota, Studies on chitin. I. Acetylation of chitin, Polym. J. 11 (1979) 27.

33 K. Kaifu, N. Nishi, T. Komai, Preparation of hexanoyl, decanoyl and dodecanoyl chitin, J. Polym. Sci., Part A: Polym. Chem. 19 (1981) 2361.

R.A.A. Muzzarelli, in: H.F. Mark, N.M. Bikales, C.G. Overberger, G. Menges (Eds.), 2nd Edition, Encyclopedia of Polymer Science and Engineering, Vol. 3, Wiley, New York, 1984, p. 435.

R.A.A. Muzzarelli (Ed.), Natural Chelating Polymers, Pergamon Press, NewYork, 1973, p. 83.

Gavhave, Yogeshkumar N. et al. International Journal of Research in Pharmaceutical and Biomedical Research, Vol. 4(1), Jan- March 2013, 312-331.

George A.F.Roberts, Progress on Chemistry and Application of Chitin and its Derivatives, Vol. XIII(2008) , 7-15.

Web site , on 24th June 2016).

Chitosan Market Analysis Report by Grand View Research Inc, April 2016.


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