Probing a Plausible Mechanistic and Stable Intermediate Route in Oxidative Hydroxylation of Formamideby Xanthine Oxidase.
Abstract
KEY WORDS: Xanthine Oxidase, Formate, CarbamateandMolybdenum
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Pincher, P., Nivorozhkin, A., and Szabo, C., (2006). Therapeutic effects of xanthine oxidase inhibitors: Renaissance half a century after the discovery of Allupurinol. Pharmacol.Rev. 58, 87-114.,
Berry, C.E., and Hare, J. M., (2004).Xanthine oxidoreductase and cardiovasculardisease: Molecular mechanism and pathysiological implications. J. physiol., 555, 589-606.
Enroth, C., Eger, B. T., Okamoto, T., Nishino, T., and Pai, E. F., (2000). Crystal structure of bovine milk xanthine oxidase dehydrogenase and xanthine oxidase:Structure-based mechanism of conversion. Proc. Net. Acad. Sci., 97, 10723-107228.
Matsumoto, K., Okamoto, K., Hille, R., Egerr, B. T., Pai, E. F., and Nishino, T., (2004). The crystal structure of XOR during catalysis: Implication for reaction mechanism and enzyme inhibition. Proc. Nat. Acad. Sci. 101, 7931-7936
Hille, R., and Massey, V., (1981).Studies on the oxidative half-reaction of xanthine oxidase. J. Bio. Chem., 256, 9090-9095
Fukunari, A., Okamoto, T., Nishino, T., Eger, B.T., Pai, E. F., Kamezawa, M., Yamada, I., and Kato, N., (2004). Y-700[1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl)]-1H-pyrazole-4 carboxylic Acid]: A Potent Xanthine oxidoredctase Inhibitor with Hepatic Excretion. J. Am. Pharm. 311, 519-528.
Al-Omer, A.M., El-Subbagh, I. H., Beedham, C., and Smith J., (2005).Role of Molybdenum hydroxylase in disease. Saudi Pharm. J., 13. (1) 1-13.
Matsumoto, K., Okamoto, K., Hille, R., Egerr, B. T., Pai, E. F., and Nishino, T., (2004). The crystal structure of XOR during catalysis: Implication for reaction mechanism and enzyme inhibition. Proc. Nat. Acad. Sci. 101, 7931-7936.
Liu, C. L., and Leonard E. M., (1984).Formate dehydrogenase AO Clostridium Pasteurianum. J.Bacteriol. 159(1), 375-330
Matsumoto, K., Okamoto, K., Hille, R., Egerr, B. T., Pai, E. F., and Nishino, T., (2004). The crystal structure of XOR during catalysis: Implication for reaction mechanism and enzyme inhibition. Proc. Nat. Acad. Sci. 101, 7931-7936.
Ilich, P., andHille, R., (1999). Mechanismofformamide hydroxylation catalyzed by Molybdenum- Dithiolene complexes: A model of xanthine oxidase reactivity. J. Phys. Chem., 103, 5406-5412.
Ardenne, S.C.D., and Edmondson, D.E., (1990). Kinetic isotope effect studies on milk xanthine oxidase and on chiken liver xanthine dehydrogenase. J. Am. Chem. 29, 9046-9052
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