Synthesis, Characterization and Study of Biological Activity of Heterocyclic Compounds Derivatives
Abstract
The research was designed to synthesize chemically -2-amino thiadiazol derivatives and conversion to schiffs base the principle synthesis of these compound was too involved two steps , the first step is by the thermal cyclization of thiosemicarbazied with carbon disulfide in the presence of anhydrous sodium carbonate absolute ethanol to give 2- amine– 5– thiolo -1,3,4- heterocycle and the second step is schiffs base formation by reflux of aldehyde or keton with 2- amino-5-mecapto -1,3,4- thiadiazole in the presence of ethanol. The chemical structures of all prepared compound were confirmed by spectral data FT-IR and H-NMR . The synthesized compounds were evaluated for their antimicrobial activity against two Gram positive bacteria two Gram negative bacteria. Some compounds showed good antimicrobial activity.
Keywords: amine, compound, confirm, data, ethanol, h gram positive, gram negative, heterocyclic compounds, thio, thiosemicarbazide, value
Keywords: thiosemicarbazide, amine, thio, confirm, compound, data, value, ethanol, heterocyclic compounds, gram positive, gram negative
Full Text:
PDFReferences
Cite this Article: Muhamed Islam Amar. Synthesis, Characterization and Study of Biological Activity of Heterocyclic Compound Derivatives. International Journal of Chemical and Molecular Engineering 2019; 5(2): 62–67p.
Refbacks
- There are currently no refbacks.