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Mechanical Studies and Thermal Kinetics of Isoniazid Crystals

Ramachandran Esakki, Sundaram Ramukutty


Single crystals of isoniazid were crystallized by slow solvent evaporation method. The crystal structure was confirmed using single crystal X-ray diffraction analysis. Micro hardness was estimated and work hardening coefficient and Newtonian resistance pressure of the crystal were determined. Kinetic analysis of the thermogravimetric data was carried out by using Coats-Redfern relation. Activation energy, frequency factor and order of reaction were also calculated. Arrhenius equation for isoniazid is k=0.43×105e–79103/RT mol–1s–1. Thermodynamic parameters were also determined

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Macedo RO, Aragao CFS, do Nascrimento TG, et al. Application of Thermogravimetry in the Quality Control of Chloranfenicol Tablets. J. Therm. Anal. Cal. 1999; 56: 1323–7p.

Moura EA, Correia LP, Pinto MF, et al. Thermal Characterization of the Solid State and Raw Material Fluconazole by Thermal Analysis and Pyrolysis Coupled to GC/MS. J. Therm. Anal. Cal. 2010; 100: 289–93p.

Ramukutty S, Jeyasudha R, Ramachandran E. Mechanical and Thermal Studies of Metronidazole Crystals. Indian J Phys. 2013; 87: 1001–4p.

Ramukutty S, Ramachandran E. Mechanical and Thermal Studies on Gel Grown Racemic Ibuprofen Crystals. World J Sci and Technol. 2012; 2: 36–8p.

Mott BW. Microindentation Hardness Testing. Butterworth Scientific Publications, London. 1956.

Hays C, Kendall EG. An Analysis of Knoop Microhardness. Metallography. 1973; 6: 275–82p.

Coats AW, Redfern JP. Kinetic Parameters from Thermogravimetric Data. Nature. 1964; 201: 68–9p.

Jensen LH. The Crystal Structure of Isonicotinic Acid Hydrazide. J Am Chem Soc. 1954; 76: 4663–7p.

Onitsch EM. Uber die Mikrohirte der Metalle. Mikroskopie. 1947; 131–51p.

Joshi R, Pandya JR. Application of Modified Kick’s Law to Rhombohedral Crystals: Calcite. Cryst Res Technol. 1991; 26: 433–40p.


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