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Kinetic and Mechanistic Study of Oxidation of Benzydamine Hydrochloride by Permanganate (VII) in Acidic Medium

V. Shastry, B. C. Sateesh, S. Shashidhar, T. N. Padmini, K. S. Ravindra


The kinetics and mechanism of Permanganate (Mn (VII)) oxidation of Benzydamine hydrochloride (B.HCl) in acidic medium has been studied at 26 ± 0.1°C. The reaction shows first order dependence in [Mn (VII)], less than unit order in [B.HCl] and fractional order dependence in [H2SO4]. Variation of ionic strength by the addition of KCl has no significant effect on the rate. The stoichiometry of the reaction is found to be 1:4 and the main oxidative products were toluene, dimethyl aza propionic acid and benzoic acid. A mechanism involving formation of complex has been proposed and the reaction constants involved in the different steps of mechanism are calculated. Activation parameters with respect to slow step of the mechanism are calculated and tabulated. The rate constant of reaction is found to be 1.960 × 10−3 s-1.

Keywords: benzydamine hydrochloride, oxidation, potassium permanganate

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