Formation and Microbic study of crown ethers on Sugar glycolipid and its analogues.

Abstract

Cown Ethers are cyclical polyethers exposed via Pederson in 1967. Buildings of three characteristic ethers are assumed below in scheme of formation. The public terms of these ethers contain a quantity as a preface to elect the overall amount of atoms in the ring and a number as a suffix to designate the number of oxygen atoms in the ring. Pederson shared the Nobel Prize in Chemistry in 1987 with Cram and Lehn for work in this area.Two new thiadiaza- and triaza-crown ethers on n-dodecyl mannopyranoside have been synthesized and characterized by proton, carbon NMR, high resolution mass spectrometry CHN analysis and FTIR. The antibacterial activities of synthesized macrocycles and their analogues was performed against two gram-negative and two gram-positive bacteria in two cultural media.

Keywords: macrocycles, mannose, glycolipids, antibacterial, crown ethers.