Synthesis, Characterization and Study of Biological Activity of Heterocyclic Compounds Derivatives

Abstract

The research was designed to synthesize chemically -2-amino thiadiazol derivatives and conversion to schiffs base the principle synthesis of these compound was too involved two steps , the first step is by  the thermal  cyclization of  thiosemicarbazied with carbon disulfide  in the presence  of anhydrous  sodium  carbonate  absolute ethanol to give  2- amine– 5– thiolo -1,3,4- heterocycle and the second step is schiffs  base  formation by reflux  of aldehyde or keton  with 2- amino-5-mecapto -1,3,4- thiadiazole in the presence of ethanol. The chemical structures of all prepared compound were confirmed by spectral data FT-IR and H-NMR . The synthesized compounds were evaluated for their antimicrobial activity against two Gram positive bacteria two Gram negative bacteria. Some compounds showed good antimicrobial activity.

Keywords: amine, compound, confirm, data, ethanol, h gram positive, gram negative, heterocyclic compounds, thio, thiosemicarbazide, value

Keywords:  thiosemicarbazide, amine, thio, confirm, compound, data, value, ethanol, heterocyclic compounds, gram positive, gram negative