Thermal Decomposition Kinetics of Mefenamic Acid Crystals
Abstract
Single crystals of mefenamic acid were crystallized by gel growth method for the first time in literature. Crystal structure was confirmed using single crystal X-ray diffraction analysis. Kinetic analysis was made from the isothermal thermogravimetric analysis/differential thermal analysis (TGA/DTA) data using Coats–Redfern (CR) relation. Thermodynamic parameters were also determined. Arrhenius equation for mefenamic acid is k = 0.28 × 109 e–116551/RT mol–1s–1. Keywords: kinetic analysis, mefenamic acid, thermal analysisReferences
Macedo R.O., Aragao C.F.S., do Nascimento T.G., et al. Application of thermogravimetry in the quality control of chloranfenicol tablets, J Therm Anal Cal. 1999; 56: 1323–7p.
Moura E.A., Correia L.P., Pinto M.F., et al. Thermal characterization of the solid state and raw material fluconazole by thermal analysis and pyrolysis coupled to GC/MS, J Therm Anal Cal. 2010; 100: 289–93p.
Ramukutty S., Ramachandran E. Mechanical and thermal studies on gel grown racemic ibuprofen crystals, World J Sci Technol. 2012; 2: 36–8p.
Ramukutty S., Jeyasudha R., Ramachandran E. Mechanical and
thermal studies of metronidazole crystals, Indian J Phys. 2013; 87: 1001–4p.
Ramachandran E., Ramukutty S., Jeyasudha R. Thermal kinetics of gel grown diclofenac drug crystals, TEPE. 2013; 2: 44p.
E. Ramachandran E., Ramukutty S. Kinetic analysis on the thermal decomposition of tinidazole crystals, Int J Solid State Mater. 2014; 1: 1–4p.
McConnell J.F., Company F.Z. N-(2,3-Xylyl)anthranilic acid, C15H15NO2, mefenamic acid, Cryst Struct Commun. 1976; 5: 861–4p.
Coats A.W., Redfern J.P. Kinetic parameters from thermogravimetric data, Nature. 1964; 201: 68–9p.
