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Studies on Interaction of SDS with HPMC Using Central Composite Design

Mohammad Kamil, Ajeet Yadav


The conductivity measurements were used to study the interaction between non-ionic biopolymers, hydroxypropyl methyl cellulose (HPMC) and the anionic surfactant- sodium dodecyl sulphate (SDS) in aqueous solutions of different concentrations and at temperatures along with the use of Response Surface Methodology (RSM). Calculations were made of the free energies of aggregation ΔGagg, micellization (Gmic), and transfer (Gt), all of which are connected to the bonding interaction between the surfactant and the polymer. The absence of a positive value for Gt verified the viability of contact between the surfactant and the polymer. An experimental design using response surface methodology (RSM) was applied to assess factors interactions and empirical models regarding the physicochemical response variable, conductivity. The main effects of the various independent factors were determined at five different temperatures by using a Central composite design (CCD). Three factors have been analysed in terms of their impact on conductivity such as polymer (HPMC) concentration, surfactant (SDS) concentration and temperature. Analysis of variance (ANOVA) results indicated that the proposed quadratic model successfully interpreted the experimental data with high coefficients of determination (R2) value of 0.9940. Low significance probability, < 0.0001 indicates the statistical significance of the proposed model. This provides readjustment of the second-order regression model with the experimental data.

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