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Toxicity, teratogenicity, and genotoxicity of Nicotian tabacum L. and Nicotiana gluaca G. : A review

Najat Ramadan El zawia, Abdelhamid Mohamed Abdalla Elyasserib

Abstract


Poisoning plant cause significant losses of livestock every year in some countries which lead to birth defects or death. Records of harmful effects by many of these plants are based solely on poisoning of livestock rather than on actual cases of human ingestion. Nicotiana tabacum and Nicotiana gluaca have been medicinally used and considered as toxic and teratogens. They are contains toxic piperidine and pyridine alkaloids. These alkaloids are acutely toxic and teratogenicity to human, animals and causing mutation whish may lead to cancer or death. This paper aims to present a review of some existing studies and statues of the toxicity, teratogenicity and mutagenicity effect of N. tabacum and N. gluaca, to benefit from their results and conclusions .

key words: N. tabacum, N. gluaca, toxicity, teratogenicity, mutagenicity.

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