RECENT DEVELOPMENTS ON VOLATILE DEEP EUTECTIC SOLVENTS FOR APPLICATION IN CRYSTALLIZATION OF PHARMACEUTICAL COMPOUNDS.

Abstract

Crystallization is one of the most effective separations and purification methods used in the pharmaceutical and fine chemical industries. Volatile organic solvents are widely used in the crystallization of pharmaceutical compounds. Some properties of these solvents such as volatility, instability, combustibility,unpredictable nature, and toxicity are undesirable. In the
recent years solvents known as ionic liquids and deepeutectic solvents (DES) derived from ionic liquidsgain importance due to the interesting properties as solvents. Application of DES in numerous and diverse fields like food, cosmetic, chemical and pharmaceutical industries is highly desirable owing to their stability, low melting point, non-volatility, better bio- degradability, non-toxic and environmentally sustainable properties. It is time to examine the use of this class of solvents in the field of crystallization. The role of green solvents for the crystallization process, and the methods of preparing volatile deep eutectic solvents by usingindustrial Active pharmaceutical ingredient termed as API as one of thecomponents is summarized.An eutectic mixture having a lower melting point is formed when two components capable of forming hydrogen bond network are mixed in optimal ratio. The feasibility of the use of VODES in the crystallization of API and the scope for implementation in the pharmaceutical industry are reviewed.