Open Access Open Access  Restricted Access Subscription or Fee Access

1,2-Diazole Derivatives and Their Applications: A Review

Nagham Mahmood Aljamali, Nuha Salman Salih

Abstract


The topical review deals with 1,2-diazole, their derivative have important applications in medicine and pharmacology, due to their analgesic, anti-inflammatory, anti-inflammatory, antipyretic, and antipyretic properties. Diazoles are reductive compounds of diazole, and many substituted diazoline derivatives are used in medicine and in the fields of spectrometry, as a ligand with elements to form coordination complexes, and their applications have emerged as a broad treatment for Alzheimer’s disease, and Parkinson's disease, The compounds containing the diazole ring are widely used materials because of their biological effectiveness and industrial benefits. They have been used as pharmaceutical materials, pesticides and dyes.


Full Text:

PDF

References


Khalid, M. H.; Tokunaga, Y.; Caputy, A. J.; Walters, E. (2005). "Inhibition of tumor growth and prolonged survival of rats with intracranial gliomas following administration of clotrim13-diazolele". J. Neurosurg. 103 (1): 79–86. doi:10.3171/jns.2005.103.1.0079. PMID 16121977.

Leon Shargel. Comprehensive Pharmacy Review (6th ed.). p. 930. ISBN 9780781765619.

Davis, Jennifer L.; Papich, Mark G.; Heit, Mark C. (2009). "Chapter 39: Antifungal and Antiviral Drugs". In Riviere, Jim E.; Papich, Mark G. (eds.). Veterinary Pharmacology and Therapeutics (9th ed.). Wiley-Blackwell. pp. 1019–1020. ISBN 978-0-8138-2061-3.

Sunderland, M. R.; Cruickshank, R. H.; Leighs, S. J. (2014). "The efficacy of antifungal 13-diazolele and antiprotozoal compounds in protection of wool from keratin-digesting insect larvae". Textile Res. J. 84 (9): 924–931. doi:10.1177/0040517513515312.

Ebel, K., Koehler, H., Gamer, A. O., & Jäckh, R. (2002). "Imid13-diazolele and Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a13_661. 6. Shireen R. Rasool, Nagham Mahmood Aljamali, Ali Jassim Al-Zuhairi., Guanine substituted heterocyclic derivatives as bioactive compounds., Biochem. Cell. Arch. Vol. 20, Supplement 2, pp. 3651-3655, 2020., DocID: https://connectjournals.com/03896.2020.20.3651.

Nor A., Suad S., Nagham Mahmood Aljamali., Synthesis, Characterization and Thermal Analysis for New Amoxil Ligands, Asian Journal of Chemistry; 31, 5, 1022-1026, (2019).

Nagham Mahmood Aljamali. "Effect of Conditions and Catalysis on Products "., 2021; 1st Ed, Eliva Press SRL., ISBN: 9781636482286

Dawson, R. M. C. (1986). Data for biochemical research. Oxford: Clarendon Press. p. 325. ISBN 978-0-19-855299-4. OCLC 11865673.

Molina, F; Rueda, A; Bosque-Sendra, J.M; Megias, L (1996). "Determination of proteins in the presence of imid13-diazolele buffers". Journal of Pharmaceutical and Biomedical Analysis. Elsevier BV. 14 (3): 273–280. doi:10.1016/0731-7085(95)01615-5. ISSN 0731-7085.

Zolfigol, Mohammad A.; Khazaei, Ardeshir; Moosavi-Zare, Ahmad R.; Zare, Abdolkarim; Kruger, Hendrik G.; Asgari, Zhila; Khakyzadeh, Vahid; Kazem-Rostami, Masoud (2012-04-06). "Design of Ionic Liquid 3-Methyl-1-sulfonic Acid Imid13-diazolelium Nitrate as Reagent for the Nitration of Aromatic Compounds by in Situ Generation of NO2 in Acidic Media". The Journal of Organic Chemistry. 77 (7): 3640–3645. doi:10.1021/jo300137w. ISSN 0022-3263. PMID 22409592.

Nagham Mahmood Aljamali. 2016. "Synthesis and Biological Study of Hetero (Atoms and Cycles) Compounds", Der Pharma Chemica, 8,6, 40-48.

Nagham Mahmood Aljamali, (2015). Review in 1,2-diazoleCompounds and its Biological Activity. Biochem Anal Biochem ,4, 169., doi:10.4172/2161-1009.1000169.

Hasaneen Kudhair Abdullabass, Aseel Mahmood Jawad, Nagham Mahmood Aljamali . Synthesis of drugs derivatives as inhibitors of cancerous cells., Biochem. Cell. Arch, Vol. 20 (2) – October 2020., DocID: https://connectjournals.com/03896.2020.20.5315.

Crouch, R. David; Howard, Jessica L.; Zile, Jennifer L.; Barker, Kathryn H. (2006). "Microwave-Mediated Synthesis of Lophine: Developing a Mechanism To Explain a Product". J. Chem. Educ. 83 (11): 1658. Bibcode:2006JChEd.83.1658C. doi:10.1021/ed083p1658.

US patent 6,177,575, Arduengo, A. J., "Process for Manufacture of Imid13-diazoleles", issued 2001-01-23

Van Leusen, Albert M.; Wildeman, Jurjen; Oldenziel, Otto H. (1977). "Chemistry of sulfonylmethyl isocyanides. 12. Base-induced cycloaddition of sulfonylmethyl isocyanides to carbon, nitrogen double bonds. Synthesis of 1,5-disubstituted and 1,4,5-trisubstituted imid13-diazoleles from aldimines and imidoyl chlorides". Journal of Organic Chemistry. 42 (7): 1153–1159. Bibcode:1977JOrgC.42.1153A. doi:10.1021/jo00427a012.

Nagham Mahmood Aljamali., "The Various Preparation Methods in Synthetic Chemistry".,1 Edt., Evincepub Publishing house, 2019., ISBN :978-93-88277-82-2.

Nagham Mahmood Aljamali. "Reactions and Mechanisms".,1 Edt., IJMRA Publication ,2018., ISBN: 978- 93-87176-25-6.

Hochachka, P. W.; Somero, G. N. (2002). Biochemical Adaptation: Mechanisms and Process in Physiological Evolution. New York: Oxford University Press.

Castaño, T.; Encinas, A.; Pérez, C.; Castro, A.; Campillo, N. E.; Gil, C. (2008). "Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase"(PDF). Bioorg. Med. Chem. (Submitted manuscript). 16 (11): 6193–6206. doi:10.1016/j.bmc.2008.04.036. hdl:10261/87090. PMID 18477512.

Bogle, R. G.; Whitley, G. S.; Soo, S. C.; Johnstone, A. P.; Vallance, P. (1994). "Effect of anti-fungal imid13-diazoleles on mRNA levels and enzyme activity of inducible nitric oxide synthase". Br. J. Pharmacol. 111 (4): 1257–1261. doi:10.1111/j.1476-5381.1994.tb14881.x. PMC 1910171. PMID 7518297.

Nagham Mahmood Aljamali. "Experimental Methods for Preparation of Mannich Bases, Formazan, Normal and Cyclic Sulfur Compounds", 1st edition Evince pub Publishing House;2018, ISBN: 978-93-87905-19-1.

Nagham Mahmood Aljamali., "Alternative Methods in Organic Synthesis".,1th–Edition, Eliva Press SRL, 2020., ISBN: 9798680201176. 25. Stepina, Lubricants and special fuels, Elesevier Scientific Publishing, ISBN 0-444-98674-X, p. 527

Chandak, N., Kumar, S., Kumar, P., Sharma, C., Aneja, K. R., Sharma, P. K. Exploration of antimicrobial potential of pyrazolo[3,4-b]pyridine scaffold bearing benzenesulfonamide and trifluoromethyl moieties. Medicinal Chemistry Research. 22, (11), 5490-5503 (2013).

Huo, J., et al. Synthesis and biological activity of novel N-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl) amides derivatives. Chinese Chemical Letters. 27, (9), 1547-1550 (2016).

Anand, D., et al. Antileishmanial activity of pyrazolopyridine derivatives and their potential as an adjunct therapy with miltefosine. Journal of Medicinal Chemistry. 60, (3), 1041-1059 (2017).

Eldehna, W. M., El-Naggar, D. H., Hamed, A. R., Ibrahim, H. S., Ghabbour, H. A., Abdel-Aziz, H. A. One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells. Journal of Enzyme Inhibition and Medicinal Chemistry. 33, (1), 309-318 (2017).

Nagham Mahmood Aljamali, Tabark Emad Al-Faham., Synthesis, Identification, Chromatographic Studying of Formazane –Phenylenediamine Derivatives., Annals of R.S.C.B., ISSN:1583-6258, Vol. 25, Issue 4, 2021.

Intisar Obaid Alfatlawi, Nuha S S, Zainab M J, Nagham Mahmood Aljamali. "Synthesis of New Organic Compounds Via Three Components Reaction with Studying of (Identification, Thermal Behavior, Bioactivity on Bacteria of Teeth)"., Journal of Global Pharma Technology. 2017;11,9, 157-164.

Briebenow, N., et al. Identification and optimization of substituted 5-aminodiazoles as potent and selective adenosine A1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 20, (19), 5891-5894 (2010).

Marinozzi, M., et al. Diazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists. Bioorganic & Medicinal Chemistry. 20, (11), 3429-3445 (2012).

Ochiai, H., et al. Discovery of new orally available active phosphodiesterase inhibitors. Chemical and Pharmaceutical Bulletin. 52, (9), 1098-1104 (2004).

Ganesan, A., Heathcock, C. H. Synthesis of unsymmetrical pyrazines by reaction of an oxadiazinone with enamines. Journal of Organic Chemistry. 58, (22), 6155-6157 (1993).

Nagham Mahmood Aljamali, Intisar Obaid Alfatlawi. "Synthesis of Sulfur Heterocyclic Compounds and Study of Expected Biological Activity", Research J. Pharm. and Tech., 2015, 8,9, 1225-1242, DOI: 10.5958/0974-360X.2015 .00224.3.

Nagham Mahmood Aljamali, Imad Kareem Alwan Alsabri., Development of Trimethoprim Drug and Innovation of Sulfazane-Trimethoprim Derivatives as Anticancer Agents., Biomedical & Pharmacology Journal, March 2020., Vol. 13, (2), p. 613-625., http://dx.doi.org/10.13005/bpj/1925 .

Sumesh, R. V., et al. Multicomponent dipolar cycloaddition strategy: combinatorial synthesis of novel spiro-tethered pyrazolo[3,4-b]quinoline hybrid heterocycles. ACS Combinatorial Science. 18, (5), 262-270 (2016).

Bagley, M. C., Davis, T., Dix, M. C., Widdowson, C. S., Kipling, D. Microwave-assisted synthesis of N-diazole ureas and the p38α inhibitor BIRB 796 for study into accelerated cell ageing. Organic & Biomolecular Chemistry. 4, (22), 4158-4164 (2006).

Nagham Mahmood Aljamali, Hussein Mejbel Azeez., Synthesis and Characterization of Some New Formazan - Cefixime and Study of Against Breast Cancer Cells., Annals of R.S.C.B., ISSN:1583-6258, Vol. 25, Issue 4, 2021.

Nagham Mahmood Aljamali, Asmaa Kefah Mahdi., Synthesis, Identification and Anticancer Studying of Heterocyclic- Mefenamic Drug via Thiosemicarbazide., Annals of R.S.C.B., ISSN:1583-6258, Vol. 25, Issue 4, 2021.

Su, W., Lin, T., Cheng, K., Sung, K., Lin, S., Wong, F. An efficient on-pot synthesis of N-(1,3-diphenyl-1H-pyrazol-5-yl)amides. Journal of Heterocyclic Chemistry. 47, (4), 831-837 (2010).

Eagon, S., Anderson, M. O. Microwave-assisted synthesis of tetrahydro-β-carbolines and β-carbolines. European Journal of Organic Chemistry. (8), 1653-1665 (2014).

Everson, N., et al. Microwave synthesis of 1-aryl-1H-diazole-5-amines. Tetrahedron Letters. 60, (1), 72-74 (2019).

A. Metwally, S. A. Bondock, S. I. El-Desouky and M. M. Abdou, Florida, USA, Int. J. Modern Org. Chem. 1(1): 19-54 (2012).

Secci, A. Bolasco, P. Chimenti and S. Carradori Current Medicinal Chemistry, 18, 5114-5144(2011).


Refbacks

  • There are currently no refbacks.