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SYNTHESIS OF NICOTINE CORE UNIT OF 2-NITRO-3-PHENYLPROPAN-1-OL FROM BAYLIS-HILLMAN ADDUCTS DERIVED FROM NITRO OLEFINS.

sivakumar kumar, A. R.N. Vaishnavi, K. Mohankrishnan

Abstract


The Baylis-Hillman adducts derived from nitroolefins have been conveniently transformed into 2- nitro-3-phenylpropan-1-ol via simple reaction condition. These compounds have been demonstrated for the synthesis of reduction olefin is highly biological reactive compounds. This novel nitro derivative of the BH adduct was simply treated with mole percentage of iron and acetic acid in reactive condition. Hence this novel nicotine core unit compounds were very intrusting and new opportunities for the preparation of nicotine molecule. Nitroolefinic compounds are highly withdrawing nature of the polymeric molecules. Hence this molecule converted to nicotine core unit is highly biological application part of drug compounds. Synthesis of heterocyclic compounds is very important in the field of nitroolefinic compounds since these heterocyclic moieties are integral part of the many bio active molecules especially in pesticides and herbicides. Moreover, this heterocyclic compound is very challenging area in the field of organic chemistry. Usually, complex organic molecules are synthesized by multistep reaction sequence. Secondary alcohol has become very attractive and useful strategy which minimizes the reaction steps to achieve the target complex organic compounds with high yields. Nitro compounds easily converted to amino acid in the presence of reduction reagent at suitable reaction condition apply to nicotine molecule, which was converted into many interesting molecules on several occasions.

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