Advance in the Synthesis of Oxadiazole Based Heterocyclic Compound

Abstract

The five members of the heterocyclic ring 1,3,4-oxadiazole are necessary for the production of strong bioactive molecules. Numerous pharmacological effects, including anti-inflammatory, antibacterial, anticancer, antitubercular, anticonvulsant, anti-HIV, hypoglycemic, and antioxidant qualities, are exhibited by this intriguing class of chemicals. We have created four novel 1,3,4-oxadiazole compounds in the continuing study, which are sourced from the NSAID Ibuprofen. Melting point analysis and TLC were used to verify the compounds' purity. Open capillary methods were used to ascertain the melting point, and it was left unaltered. The structure of the four freshly synthesized compounds was confirmed using FTIR and 1HNMR spectroscopy. The creation of procedures for the environmentally friendly synthesis of materials and chemicals is referred to as &outgreen synthetic protocol. Various methods that are both energy-efficient and environmentally friendly, including microwave irradiation, ultrasound-assisted synthesis, photo-catalysis employing ultraviolet, visible, and infrared light, molecular sieving, grinding, milling techniques, and others, are employed in the creation of diverse biologically active substances. These procedures are regarded as sustainable technology and have gained value as green protocols for the synthesis of novel medicinal compounds because they have several advantages over traditional synthetic techniques. This idea is the basis for the synthesis of oxadiazole derivatives using a microwave irradiation approach, which decreases the generation of byproduct and increases the product yield quantitatively in a shorter reaction time. Because of this, the synthesis of pharmacological molecules under microwave irradiation adheres to a green chemistry strategy, which uses a set of guidelines to reduce or eliminate the use of dangerous and toxic ingredients in the design, production, and use of chemicals. By using cleaner solvents, catalysts, and appropriate reaction conditions, this strategy helps to reduce environmental pollution and boosts energy efficiency and atom economy.